HIST2H3C and WHSC1

Number of citations of the paper that reports this interaction (PMID 21720545)
18

Data Source:
BioGRID (unspecified method)

		HIST2H3C	WHSC1
Gene Name		histone cluster 2, H3c	Wolf-Hirschhorn syndrome candidate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Chromatin Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Chromatin Organization Transcription, DNA-templated Anatomical Structure Morphogenesis Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	7 interactors: APP AR ESR1 HIST1H3A HIST2H3C HIST3H3 MDC1
Entrez ID		126961	7468
HPRD ID		11822	04259
Ensembl ID			ENSG00000109685
Uniprot IDs		Q71DI3	O96028
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	DNA Methylation On Cytosine Chromatin Silencing At RDNA Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Chromatin Silencing DNA Metabolic Process DNA Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic DNA Modification Growth Negative Regulation Of Integrin Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Gene Silencing Regulation Of Body Fluid Levels Wound Healing Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Developmental Growth Involved In Morphogenesis Cell Growth Response To Wounding Collateral Sprouting In Absence Of Injury Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Steroid Hormone Stimulus Regulation Of Integrin Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth DNA-templated Transcription, Initiation Axon Choice Point Recognition Steroid Metabolic Process Chromosome Organization Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy
Tagcloud ?			aberrantly amenable backgroundhistone chemotherapies conclusionsour ctd docked h3k27 h3k36 h3k4 h3k79 h3k9 h4k20 hmtases mer methylating methylations mmset modifiers nsd nsd1 nsd2 nsd3 nsds recognizing resultsherein transferases versatility
Tagcloud (Difference) ?			aberrantly amenable backgroundhistone chemotherapies conclusionsour ctd docked h3k27 h3k36 h3k4 h3k79 h3k9 h4k20 hmtases mer methylating methylations mmset modifiers nsd nsd1 nsd2 nsd3 nsds recognizing resultsherein transferases versatility
Tagcloud (Intersection) ?