H3C14 and KAT5

Number of citations of the paper that reports this interaction (PubMedID 22081016)
57

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		H3C14	KAT5
Description		H3 clustered histone 14	lysine acetyltransferase 5
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Extracellular Exosome	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Chromatin Nucleosome Swr1 Complex Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol Cytoskeleton Nuclear Lumen Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Mitotic Spindle Pole
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H2A Acetyltransferase Activity Histone H2AK5 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptide Crotonyltransferase Activity Peptide Butyryltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Gene Expression	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Immune System Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Apoptotic Process DNA Damage Response Spermatid Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Triglyceride Biosynthetic Process Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Neural Tube Development Neurogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Interleukin-2 Production Cellular Response To Stress Sperm DNA Condensation Aggrephagy Cellular Response To Glucose Starvation Positive Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Glucose Stimulus Cellular Response To Estradiol Stimulus Cellular Senescence Membraneless Organelle Assembly DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Acetylation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Cardiogenesis
Drugs			Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS			A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		66 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CBX2 CBX4 CBX6 CBX7 CBX8 CDCA8 CDK8 CHUK DDB2 DNAJC9 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1	197 interacting genes: AGO2 ALOX12 ALX1 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 AXIN1 BACH2 BARD1 BCL3 BLZF1 BMI1 BRCA1 C1orf174 CAVIN1 CBX8 CCDC106 CCDC125 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CEP70 COXFA4L2 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DMRTB1 DNAAF6 DUSP23 E2F1 E2F4 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B FAM161A FCHO1 FSAF1 GADD45G GAPDH GEMIN7 GET4 GIGYF1 GKAP1 GMCL1 GMCL2 GOLGA2 GSTO1 GTF2E2 GTSE1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4C1 H4C14 H4C16 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 HOOK1 HSF2BP ID3 IFT20 IK IKZF3 IL9R KCTD7 KDM2B KIF24 KLF4 KPNA3 KPNA4 KPNA5 KPNA6 KRT40 KRTAP10-3 KRTAP10-9 LARP4 LMNA LONRF1 LRIF1 LRP1 LZTS1 LZTS2 MAD2L1BP MAPRE1 MCC MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PCM1 PDCD5 PFKP PHC2 PICK1 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PPP1R16A PRDM6 PTPN4 PTPRS RB1 RBPMS RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SCRN2 SERTAD2 SHISA6 SNAPIN SNRPD2 SOX5 SPATA2 SQSTM1 SRF SRSF2 SSX2IP STAT3 STMN3 STX11 SYCE1 SYN1 TAX1BP1 TBX5 TELO2 TFIP11 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UBASH3B UHRF1 UPRT YJU2 YWHAG ZBTB1 ZBTB14 ZBTB2 ZBTB8A ZC2HC1C ZEB1 ZNF24 ZNF417 ZNF511 ZNF513 ZNF526 ZNF692 ZSCAN4
Entrez ID		126961	10524
HPRD ID		11822	03245
Ensembl ID		ENSG00000203811	ENSG00000172977
Uniprot IDs		Q71DI3	Q92993
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7TAN 7U50 7U51 7U52 7U53 7UV9 7UVA 7XCR 7XCT 7XD0 7YRD 8AAG 8ATF 8AV6 8GRQ 8HQY 8HR1 8JLB 8JLD 8OL1 8VMJ 8VMN 8VO0 8VOB 8VWS 8VWT 8VWU 8VWV 8X7I 8X7J 8X7K 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9GMK 9GMR 9IPU	2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Chromosome Positive Regulation Of Biosynthetic Process Histone Binding Histone Methyltransferase Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Histone H3K4 Monomethyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Transcription Coactivator Activity Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Histone H3 Methyltransferase Activity Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Metaphase Plate Congression Histone H3K4 Methyltransferase Activity Methylation Methyltransferase Activity Acetyltransferase Activity	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Metabolic Process DNA Binding Identical Protein Binding Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Transcription By RNA Polymerase II Chromatin Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?