HIST2H3C and ELP3

Number of citations of the paper that reports this interaction (PMID 11818576)
39

Data Source:
BioGRID (enzymatic study)

		HIST2H3C	ELP3
Gene Name		histone cluster 2, H3c	elongator acetyltransferase complex subunit 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Core Binding Protein Binding Phosphorylase Kinase Regulator Activity H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Neuron Migration TRNA Wobble Uridine Modification Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Central Nervous System Development Positive Regulation Of Cell Migration Histone H3 Acetylation Histone H4 Acetylation Regulation Of Protein Kinase Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	6 interactors: CTDP1 HIST1H4A HIST2H3C IKBKAP SMAD1 SMURF1
Entrez ID		126961	55140
HPRD ID		11822	10936
Ensembl ID			ENSG00000134014
Uniprot IDs		Q71DI3	Q9H9T3
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Gene Silencing DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Chromatin Silencing Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic BMP Signaling Pathway DNA-templated Transcription, Elongation DNA Modification Cellular Protein Modification Process Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Histone H4-K20 Demethylation Cellular Response To Transforming Growth Factor Beta Stimulus Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Ossification Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Primary MiRNA Processing Protein Complex Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Osteoblast Fate Commitment Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Exit From Mitosis SMAD Protein Complex Assembly Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Protein Metabolic Process Mesodermal Cell Fate Commitment Methylation Regulation Of Megakaryocyte Differentiation Protein Localization To Cell Surface Receptor Catabolic Process Cardiac Muscle Cell Proliferation
Tagcloud ?			aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated
Tagcloud (Difference) ?			aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated
Tagcloud (Intersection) ?