HIST2H3C and SETD1A

Number of citations of the paper that reports this interaction (PMID 22266653)
13

Data Source:
BioGRID (enzymatic study)

		HIST2H3C	SETD1A
Gene Name		histone cluster 2, H3c	SET domain containing 1A
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Chromosome Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Histone H3-K4 Methylation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	7 interactors: DPY30 EP300 HIST1H3A HIST2H3C LBP TP53 WDR5
Entrez ID		126961	9739
HPRD ID		11822	13795
Ensembl ID			ENSG00000099381
Uniprot IDs		Q71DI3	O15047
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Chromatin Organization Chromosome Organization Methylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3-K4 Methylation Peptidyl-lysine Modification Chromatin Silencing Gene Expression Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation DNA Methylation Negative Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Somitogenesis Regulation Of RNA Metabolic Process DNA Modification Negative Regulation Of Gene Expression Histone H2B Acetylation Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process ER-nucleus Signaling Pathway Regulation Of Gene Expression Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of Body Fluid Levels Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetylation Segmentation
Tagcloud ?			accomplish ash2l assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan methyltransferases missing mll1 mll3 monomethtranferase monomethylation mutagenesis rbbp5 reconstituted set1 substitutions trimethylation trithorax wdr5 wrad
Tagcloud (Difference) ?			accomplish ash2l assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan methyltransferases missing mll1 mll3 monomethtranferase monomethylation mutagenesis rbbp5 reconstituted set1 substitutions trimethylation trithorax wdr5 wrad
Tagcloud (Intersection) ?