HIST2H3C and BRPF1

Number of citations of the paper that reports this interaction (PMID 21720545)
18

Data Source:
BioGRID (unspecified method, x-ray crystallography)

		HIST2H3C	BRPF1
Gene Name		histone cluster 2, H3c	bromodomain and PHD finger containing, 1
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	4 interactors: GTF2H1 HIST2H3C MEAF6 PBXIP1
Entrez ID		126961	7862
HPRD ID		11822	03875
Ensembl ID			ENSG00000156983
Uniprot IDs		Q71DI3	P55201
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Histone H3-K14 Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone H4-K12 Acetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H2A Acetylation Chromatin Silencing At RDNA Nucleotide-excision Repair, DNA Damage Removal Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Chromatin Silencing 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Histone H3 Acetylation Positive Regulation Of Viral Transcription Histone H4 Acetylation Regulation Of Metabolic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Gene Expression DNA Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Elongation DNA Modification Nucleotide-excision Repair Gene Silencing Negative Regulation Of Biosynthetic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation
Tagcloud ?			acetylates acetyllysine bonding bromodomain calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones ing5 monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally
Tagcloud (Difference) ?			acetylates acetyllysine bonding bromodomain calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones ing5 monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally
Tagcloud (Intersection) ?