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HIST2H3C and KAT2A
Number of citations of the paper that reports this interaction (PMID
16096645
)
39
Data Source:
BioGRID
(enzymatic study)
HIST2H3C
KAT2A
Gene Name
histone cluster 2, H3c
K(lysine) acetyltransferase 2A
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Extracellular Space
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
STAGA Complex
Transcription Factor TFTC Complex
Mitotic Spindle
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
H3 Histone Acetyltransferase Activity
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Biological Process
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
In Utero Embryonic Development
Somitogenesis
Neural Tube Closure
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cell Proliferation
Viral Process
Histone Deubiquitination
Telencephalon Development
Metencephalon Development
Midbrain Development
Regulation Of Protein Stability
Multicellular Organism Growth
Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Signaling by NOTCH1 HD Domain Mutants in Cancer
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HATs acetylate histones
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Pre-NOTCH Transcription and Translation
Signaling by NOTCH1
Pre-NOTCH Expression and Processing
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Chromatin organization
RNA Polymerase I Transcription
Signaling by NOTCH
Notch-HLH transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
45 interactors:
ATXN7
BATF2
BRCA1
CDK2
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
GATA2
HIST1H1B
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HIST4H4
HSD11B2
IRF1
IRF2
IRF7
MYB
MYC
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RBPJ
RELA
SIRT2
SUMO1
TACC1
TACC2
TACC3
TADA2A
TCF3
TRRAP
XRCC6
Entrez ID
126961
2648
HPRD ID
11822
03807
Ensembl ID
ENSG00000108773
Uniprot IDs
Q71DI3
Q92830
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
1F68
1Z4R
3D7C
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Chromosome Organization
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Gene Expression
Cell Cycle
Chromatin Organization
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Chromatin Silencing At RDNA
Regulation Of Cell Differentiation
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Type I Interferon Production
Organelle Organization
Regulation Of Metabolic Process
Immune System Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Type I Interferon Production
Negative Regulation Of Cell Differentiation
Chromatin Modification
DNA Methylation On Cytosine
Response To Abiotic Stimulus
Regulation Of Histone Modification
Chromatin Silencing
Regulation Of Chromosome Organization
Tagcloud
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Difference)
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Intersection)
?