HIST2H3C and ATRX

Number of citations of the paper that reports this interaction (PMID 21666679)
35

Data Source:
BioGRID (unspecified method, x-ray crystallography, x-ray crystallography, unspecified method)

		HIST2H3C	ATRX
Gene Name		histone cluster 2, H3c	alpha thalassemia/mental retardation syndrome X-linked
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Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nuclear Heterochromatin PML Body Telomeric Heterochromatin SWI/SNF Superfamily-type Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding DNA Translocase Activity Methylated Histone Binding Histone Binding Chromo Shadow Domain Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	DNA Repair DNA Methylation DNA Recombination Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nuclear Cell Cycle DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Forebrain Development Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter Sertoli Cell Development Seminiferous Tubule Development Cellular Response To Hydroxyurea Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	21 interactors: ATN1 BLM CALM1 CCSER2 DAXX EZH2 HDAC1 HDAC4 HIST1H3A HIST2H3C KIAA1377 LUC7L2 NEK1 NSD1 PTN PTPN4 RAD51 SVIL WRN ZBED1 ZNF512B
Entrez ID		126961	546
HPRD ID		11822	02069
Ensembl ID			ENSG00000085224
Uniprot IDs		Q71DI3	A4LAA3 B4DLW1 P46100
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	2JM1 2LBM 2LD1 3QL9 3QLA 3QLC 3QLN
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Organelle Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Cellular Response To Camptothecin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Response To Camptothecin Cellular Response To Radiation Response To Ionizing Radiation Negative Regulation Of Gene Expression Cellular Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process DNA Methylation Chromatin Organization Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation DNA Duplex Unwinding DNA Geometric Change Response To Stress Cellular Nitrogen Compound Metabolic Process DNA Methylation On Cytosine DNA Modification Regulation Of Cell Division Chromatin Silencing At RDNA Replication Fork Processing Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Cycle DNA-dependent DNA Replication Chromatin Modification Wound Healing Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Cycle Process Histone H4 Deacetylation DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Wounding Gene Expression Double-strand Break Repair Histone Modification
Tagcloud ?			12v2 altering banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs nras ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?			12v2 altering banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs nras ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Intersection) ?