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HIST2H3C and STAT6
Number of citations of the paper that reports this interaction (PMID
11509556
)
25
Data Source:
HPRD
(in vitro, in vivo)
HIST2H3C
STAT6
Gene Name
histone cluster 2, H3c
signal transducer and activator of transcription 6, interleukin-4 induced
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Nuclear Chromatin
Nucleoplasm
Cytoplasm
Cytosol
Membrane Raft
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Signal Transducer Activity
Protein Binding
Protein Phosphatase Binding
Identical Protein Binding
Biological Process
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription From RNA Polymerase II Promoter
T-helper 1 Cell Lineage Commitment
Negative Regulation Of Type 2 Immune Response
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Signal Transduction
Positive Regulation Of Type I Interferon Production
Mammary Gland Epithelial Cell Proliferation
Interleukin-4-mediated Signaling Pathway
Regulation Of Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Isotype Switching To IgE Isotypes
Mammary Gland Morphogenesis
Cellular Response To Hydrogen Peroxide
Cellular Response To Reactive Nitrogen Species
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Signaling by PDGF
Downstream signal transduction
Cytosolic sensors of pathogen-associated DNA
STING mediated induction of host immune responses
STAT6-mediated induction of chemokines
Innate Immune System
Drugs
Diseases
GWAS
Eosinophilic esophagitis (pediatric) (
20208534
)
IgE levels (
22075330
)
Protein-Protein Interactions
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
37 interactors:
ANKZF1
ANXA2
CEBPB
CEBPE
CEBPZ
CREBBP
DAZAP2
EEF1A1
EP300
ETS1
HIST2H3C
IFNG
IL4R
IRF4
JAK1
LITAF
NCOA1
NCOA2
NFKB1
NMI
PPARG
PRKCZ
PTPN6
RCN3
RELA
RLIM
SND1
SRC
STAT2
STAT3
TP53
TRIM24
VKORC1
WWP1
ZBTB2
ZNF407
ZNF92
Entrez ID
126961
6778
HPRD ID
11822
03302
Ensembl ID
ENSG00000166888
Uniprot IDs
Q71DI3
A8K4S9
B4DQB3
P42226
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
1OJ5
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Response To Organic Substance
Gene Expression
Regulation Of Gene Expression
RNA Metabolic Process
Response To Organic Substance
Positive Regulation Of Transcription, DNA-templated
Defense Response
Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Response To Lipid
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Immune Response
Cellular Nitrogen Compound Metabolic Process
Regulation Of Cytokine Production
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Response To Hormone
Response To Stress
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Immune System Process
Positive Regulation Of Cytokine Production
Response To Cytokine
Regulation Of Cellular Process
Response To Biotic Stimulus
Cellular Response To Hormone Stimulus
Cellular Metabolic Process
Innate Immune Response
Regulation Of Cell Differentiation
Tagcloud
?
13r
13ralpha
2rgammac
4r
alternative
chains
classical
consist
consists
crucial
exist
form
forms
gammac
hand
hematopoietic
il
instead
jak1
jak3
lack
predominantly
recently
regard
signals
transduction
transmitted
tyrosine
utilized
Tagcloud (Difference)
?
13r
13ralpha
2rgammac
4r
alternative
chains
classical
consist
consists
crucial
exist
form
forms
gammac
hand
hematopoietic
il
instead
jak1
jak3
lack
predominantly
recently
regard
signals
transduction
transmitted
tyrosine
utilized
Tagcloud (Intersection)
?