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HIST2H3C and KMT2A
Number of citations of the paper that reports this interaction (PMID
21726816
)
25
Data Source:
BioGRID
(enzymatic study)
HIST2H3C
KMT2A
Gene Name
histone cluster 2, H3c
lysine (K)-specific methyltransferase 2A
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Histone Methyltransferase Complex
MLL1 Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Core Promoter Sequence-specific DNA Binding
AT DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Transcription Regulatory Region DNA Binding
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
Biological Process
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
DNA Methylation
Chromatin Organization
Transcription From RNA Polymerase II Promoter
Protein Complex Assembly
Apoptotic Process
Negative Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Cellular Response To Drug
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
33 interactors:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
CTR9
FASLG
H3F3A
HCFC1
HCFC2
HIST1H3A
HIST1H4A
HIST2H3C
HIST3H3
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
Entrez ID
126961
4297
HPRD ID
11822
01162
Ensembl ID
ENSG00000118058
Uniprot IDs
Q71DI3
Q03164
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Peptidyl-lysine Modification
Regulation Of Gene Expression
Organelle Organization
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Gene Expression
Methylation
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Methylation On Cytosine
Peptidyl-amino Acid Modification
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Silencing At RDNA
Positive Regulation Of Cellular Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
DNA Methylation
Protein Acetylation
Cellular Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
Histone H3-K4 Methylation
DNA Modification
Histone Ubiquitination
Chromatin Silencing
Tagcloud
?
alters
associates
demethylase
h3k4
h3k4me3
hmt
hyperplastic
igf2bp2
integrative
interactive
islet
islets
jarid1
jumonji
kdm5a
kmt2b
landscape
men1
menin
methyltransferases
mll1
mll4
neuroendocrine
pancreatic
pannets
rbp2
seq
trimethylation
unbiased
Tagcloud (Difference)
?
alters
associates
demethylase
h3k4
h3k4me3
hmt
hyperplastic
igf2bp2
integrative
interactive
islet
islets
jarid1
jumonji
kdm5a
kmt2b
landscape
men1
menin
methyltransferases
mll1
mll4
neuroendocrine
pancreatic
pannets
rbp2
seq
trimethylation
unbiased
Tagcloud (Intersection)
?