H3C14 and KMT2D

Number of citations of the paper that reports this interaction (PubMedID 22266653)
50

Data Source:
BioGRID (enzymatic study)

		H3C14	KMT2D
Description		H3 clustered histone 14	lysine methyltransferase 2D
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GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Extracellular Exosome	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Gene Expression	Oocyte Growth Chromatin Organization Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Heterochromatin Formation Methylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Beta-catenin-TCF Complex Assembly
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases			Kabuki syndrome
GWAS			Chronotype ( 30696823) General cognitive ability ( 29844566) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)
Interacting Genes		66 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CBX2 CBX4 CBX6 CBX7 CBX8 CDCA8 CDK8 CHUK DDB2 DNAJC9 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1	16 interacting genes: AKT1 ASH2L CREBBP CTNNB1 ESR1 H2AC4 H2BC3 H3C1 H3C14 H4C1 MEN1 POLR2A SMAD1 SMAD9 UBC USP7
Entrez ID		126961	8085
HPRD ID		11822	03664
Ensembl ID		ENSG00000203811	ENSG00000167548
Uniprot IDs		Q71DI3	O14686 Q59FG6 Q6PIA1
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7TAN 7U50 7U51 7U52 7U53 7UV9 7UVA 7XCR 7XCT 7XD0 7YRD 8AAG 8ATF 8AV6 8GRQ 8HQY 8HR1 8JLB 8JLD 8OL1 8VMJ 8VMN 8VO0 8VOB 8VWS 8VWT 8VWU 8VWV 8X7I 8X7J 8X7K 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9GMK 9GMR 9IPU	3UVK 4ERQ 4Z4P 6O7G 8U2Y 9ATN
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Chromosome Positive Regulation Of Biosynthetic Process Histone Binding Histone Methyltransferase Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Histone H3K4 Monomethyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Transcription Coactivator Activity Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Histone H3 Methyltransferase Activity Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Metaphase Plate Congression Histone H3K4 Methyltransferase Activity Methylation Methyltransferase Activity Acetyltransferase Activity	Chromatin Remodeling Chromatin Organization Nucleus Structural Constituent Of Chromatin Nucleoplasm Nucleosome Protein-containing Complex I-SMAD Binding Protein-DNA Complex Assembly DNA Binding Chromosome Transcription Regulator Complex Stem Cell Differentiation Nucleosome Assembly Chromatin Binding Epigenetic Regulation Of Gene Expression Osteoblast Differentiation Nucleosome Organization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromatin Protein Heterodimerization Activity SMAD Protein Complex Nitric-oxide Synthase Regulator Activity Heteromeric SMAD Protein Complex MLL1/2 Complex Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Macromolecule Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Population Proliferation Protein Deubiquitination Post-translational Protein Modification Intracellular Signaling Cassette Kinase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Cellular Response To Growth Factor Stimulus Hindbrain Development Protein Localization To Chromosome Gene Expression Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Transcription By RNA Polymerase II Intracellular Signal Transduction Regulation Of Metabolic Process Protein Modification By Small Protein Removal Ubiquitin Protein Ligase Binding Response To Growth Factor Cellular Component Assembly
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