NUAK1 and FBXO25

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		NUAK1	FBXO25
Gene Name		NUAK family, SNF1-like kinase, 1	F-box protein 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Microtubule Cytoskeleton	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Regulation Of Cell Proliferation Regulation Of Cellular Senescence	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831)
Protein-Protein Interactions		6 interactors: APP CASP6 FBXO25 LATS1 PPP1CC UBC	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		9891	26260
HPRD ID		12171	16439
Ensembl ID		ENSG00000074590	ENSG00000147364
Uniprot IDs		O60285	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Cellular Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Energy Reserve Metabolic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Cellular Carbohydrate Metabolic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Axon Choice Point Recognition Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
Tagcloud ?		4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Difference) ?		4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Intersection) ?