NUAK1

Description		NUAK family kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation DNA Damage Response Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence
Pathways		Regulation of TP53 Activity through Phosphorylation
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Attention function in attention deficit hyperactive disorder ( 26174813) Brain morphology (MOSTest) ( 32665545) General glucose level in pregnancy (gestational week 30-32) ( 30324795) Lateral ventricular volume in normal aging ( 30258056) Medial thalamic nuclei volume ( 34006833) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795)
Novel Interacting Genes		2 novel interacting genes: MARK2 MRPS25
Interacting Genes		5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC
Entrez ID		9891
HPRD ID		12171
Ensembl ID		ENSG00000074590
Uniprot IDs		O60285
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Postsynapse Macromolecule Metabolic Process Nuclear Chromosome Segregation Sister Chromatid Segregation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Component Organization PTB Domain Binding Regulation Of Synapse Assembly Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Staurosporine Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Microtubule Organizing Center Chromosome Segregation Inner Cell Mass Cell Fate Commitment
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