RNF8 and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 28525740)
61

Data Source:
BioGRID (enzymatic study)

		RNF8	H2AC20
Description		ring finger protein 8	H2A clustered histone 20
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Heterochromatin Formation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496	72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		9025	8338
HPRD ID		11521	09107
Ensembl ID		ENSG00000112130	ENSG00000184260
Uniprot IDs		O76064	Q16777
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV	6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding	Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription
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