RNF8 and CHD4

Number of citations of the paper that reports this interaction (PMID 22531782)
17

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RNF8	CHD4
Gene Name		ring finger protein 8, E3 ubiquitin protein ligase	chromodomain helicase DNA binding protein 4
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleolus Midbody Site Of Double-strand Break	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Microtubule Binding Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Spermatid Development Response To Ionizing Radiation Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Spindle Assembly
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088)
Protein-Protein Interactions		35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4	17 interactors: ATM ATR CSNK2A1 EP300 HDAC1 HIST1H3A HIST3H3 IKZF4 MBD3L2 RBBP7 RNF8 RORC SMARCA4 SUMO1 TRIM27 TWIST1 XRN1
Entrez ID		9025	1108
HPRD ID		11521	04472
Ensembl ID		ENSG00000112130	ENSG00000111642
Uniprot IDs		O76064	B3KY63 F5GWX5 Q05CG6 Q14839
PDB IDs		2CSW 2PIE 4AYC 4EPO	1MM2 1MM3 2EE1 2L5U 2L75
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Double-strand Break Repair Cell Cycle Process Cellular Response To Stress Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cell Cycle Postreplication Repair Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination DNA Damage Checkpoint Protein K48-linked Ubiquitination Response To Stress Mitotic DNA Damage Checkpoint Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Toll-like Receptor 4 Signaling Pathway Recombinational Repair Protein Catabolic Process DNA Double-strand Break Processing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Cellular Response To Heat ATP-dependent Chromatin Remodeling Chromosome Organization Regulation Of Viral Transcription DNA Metabolic Process Chromatin Organization Regulation Of Gene Expression, Epigenetic Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Binding RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Rhythmic Process Cellular Metabolic Process Interaction With Symbiont Regulation Of Response To DNA Damage Stimulus Chromatin Modification Regulation Of RNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Organization Regulation Of Viral Process Regulation Of Signal Transduction By P53 Class Mediator Histone Modification Transcription, DNA-templated Chromatin Remodeling Regulation Of Metabolic Process RNA Biosynthetic Process Response To Temperature Stimulus
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Intersection) ?