RNF8 and TMEM79

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RNF8	TMEM79
Gene Name		ring finger protein 8, E3 ubiquitin protein ligase	transmembrane protein 79
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleolus Midbody Site Of Double-strand Break	Lysosomal Membrane Integral Component Of Membrane Trans-Golgi Network Membrane
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Spermatid Development Response To Ionizing Radiation Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Epithelial Cell Maturation Hair Follicle Morphogenesis Cuticle Development Regulated Secretory Pathway Positive Regulation Of Epidermis Development Establishment Of Skin Barrier Cornification
Pathways
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4	14 interactors: ABO CLEC7A PLN PLP2 RNF8 RPRM SEC22A SERP1 SFTPC SLN TEX264 TMEM100 TMPRSS4 TNMD
Entrez ID		9025	84283
HPRD ID		11521	17481
Ensembl ID		ENSG00000112130	ENSG00000163472
Uniprot IDs		O76064	Q9BSE2
PDB IDs		2CSW 2PIE 4AYC 4EPO
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Double-strand Break Repair Cell Cycle Process Cellular Response To Stress Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cell Cycle Postreplication Repair Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination DNA Damage Checkpoint Protein K48-linked Ubiquitination Response To Stress Mitotic DNA Damage Checkpoint Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Toll-like Receptor 4 Signaling Pathway Recombinational Repair Protein Catabolic Process DNA Double-strand Break Processing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Import Cellular Response To BMP Stimulus Response To Organic Substance Negative Regulation Of Transporter Activity Regulation Of ATPase Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Negative Regulation Of Calcium-transporting ATPase Activity Endothelial Cell Differentiation Histone H2A K63-linked Ubiquitination Regulation Of The Force Of Heart Contraction By Cardiac Conduction Endothelium Development Negative Regulation Of Ion Transport Negative Regulation Of Binding Carbohydrate Mediated Signaling Adrenergic Receptor Signaling Pathway Involved In Heart Process G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Cellular Response To Organic Substance Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Tendon Formation Tendon Cell Differentiation Regulation Of Relaxation Of Cardiac Muscle Response To Growth Factor Positive Regulation Of Growth Hormone Secretion Response To Carbohydrate Negative Regulation Of ATPase Activity Tendon Development Vesicle Fusion With Golgi Apparatus Regulation Of Cardiac Muscle Cell Membrane Potential Histone H2B Ubiquitination Regulation Of Calcium Ion Transport Arterial Endothelial Cell Differentiation Interstrand Cross-link Repair Regulation Of Growth Hormone Secretion Negative Regulation Of Heart Rate Sarcoplasmic Reticulum Calcium Ion Transport Blood Vessel Endothelial Cell Differentiation
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated
Tagcloud (Intersection) ?