RNF8 and MDC1

  • Number of citations of the paper that reports this interaction (PMID 18001825)
  • 277
  • Data Source:
  • HPRD (in vitro)

RNF8

MDC1

Gene Name ring finger protein 8, E3 ubiquitin protein ligase mediator of DNA-damage checkpoint 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4 37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251
Entrez ID 9025 9656
HPRD ID 11521 16252
Ensembl ID ENSG00000112130 ENSG00000137337
Uniprot IDs O76064 A1Z5I9 Q14676
PDB IDs 2CSW 2PIE 4AYC 4EPO 2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
53bp1  atm  brca1  cdk1  comparatively  coordinates  cytosol  ddr  enables  exit  flanking  genotoxic  h2a  homologous  impairs  interphase  joining  kinetochores  ligases  localize  mitosis  mitotic  plk1  properly  recombination  rnf168  s1618  spatiotemporally  ubiquitinated 
53bp1  atm  break  breaks  cajal  delays  dsb  dsbs  facilitates  facilitating  h2ax  impairs  joining  localizes  neurodegeneration  nhej  nonhomologous  partner  premature  rad51  repair  rnf8  scaffold  strand  tcab1  ubiquitylation  wd40  wdr79  wrap53beta 
Tagcloud (Difference) ?
brca1  cdk1  comparatively  coordinates  cytosol  ddr  enables  exit  flanking  genotoxic  h2a  homologous  interphase  kinetochores  ligases  localize  mitosis  mitotic  plk1  properly  recombination  rnf168  s1618  spatiotemporally  ubiquitinated 
break  breaks  cajal  delays  dsb  dsbs  facilitates  facilitating  h2ax  localizes  neurodegeneration  nhej  nonhomologous  partner  premature  rad51  repair  scaffold  strand  tcab1  ubiquitylation  wd40  wdr79  wrap53beta 
Tagcloud (Intersection) ?
53bp1  atm  impairs  joining  rnf8