RNF8 and CCDC14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF8	CCDC14
Description		ring finger protein 8	coiled-coil domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break	Cytoplasm Centrosome Cytoskeleton Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Substantia Nigra Development Protein Localization To Centrosome
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)	Intelligence (MTAG) ( 29326435)
Interacting Genes		78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496	17 interacting genes: APP CALM1 CEP63 CSNK1D CSNK1E DDX6 KDM1A MAGEA11 MAGEB4 MAPK14 PEX5 PIK3R3 PLAC9 PNKP RNF8 TXLNB UBQLN4
Entrez ID		9025	64770
HPRD ID		11521	07801
Ensembl ID		ENSG00000112130	ENSG00000175455
Uniprot IDs		O76064	J3QT39 Q49A88
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding	Regulation Of Double-strand Break Repair Regulation Of Canonical Wnt Signaling Pathway Response To Radiation DNA Damage Response Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Neuron Maturation Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Spindle Pole Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of DNA Recombination DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Cytosol Cellular Response To Nerve Growth Factor Stimulus Spindle Microtubule Regulation Of Proteasomal Protein Catabolic Process Concave Side Of Sperm Head Positive Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of DNA Metabolic Process Cellular Response To CAMP
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