RNF8 and UBE2D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF8	UBE2D2
Description		ring finger protein 8	ubiquitin conjugating enzyme E2 D2
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break	Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Protein Autoubiquitination Protein K48-linked Ubiquitination
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			(R,R)-2,3-Butanediol
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)	Alzheimer's disease (late onset) ( 30820047) Body mass index ( 26426971) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Leukocyte telomere length ( 32109421)
Interacting Genes		78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496	244 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 DCAF1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HUWE1 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NPR1 NSMCE1 OBI1 OTUB1 PDZRN3 PELI1 PHF7 PHRF1 PJA1 PJA2 PMAIP1 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF144A RNF146 RNF149 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP STAM2 STK11 STUB1 SYVN1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM11 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UFM1 UHRF1 UHRF2 UVSSA VHL VPS11 VPS18 WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		9025	7322
HPRD ID		11521	04268
Ensembl ID		ENSG00000112130	ENSG00000131508
Uniprot IDs		O76064	P62837
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV	1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6M2C 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D 7AI0 7AI1 7BOL 7R71 8B3I 8GBQ 8GCB 8GRM 8JWJ 8JWU 8V0D 8VK8 8VK9
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Zinc Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Metal Ion Binding Catabolic Process Protein Autoubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Protein Monoubiquitination Response To Stress Regulation Of Signal Transduction Immune System Process Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Protein Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Ubiquitin Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction Defense Response To Symbiont
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