RNF8 and WASL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RNF8	WASL
Gene Name		ring finger protein 8, E3 ubiquitin protein ligase	Wiskott-Aldrich syndrome-like
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleolus Midbody Site Of Double-strand Break	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Lamellipodium Actin Cap Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity	Actin Binding Small GTPase Regulator Activity Protein Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Spermatid Development Response To Ionizing Radiation Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Membrane Budding Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Axon Guidance Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Axon guidance DCC mediated attractive signaling EPHB-mediated forward signaling Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking EPH-Ephrin signaling Nephrin interactions eNOS activation and regulation Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4	47 interactors: ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BAIAP2 CDC42 CTTN DNMBP EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		9025	8976
HPRD ID		11521	05448
Ensembl ID		ENSG00000112130	ENSG00000106299
Uniprot IDs		O76064	O00401
PDB IDs		2CSW 2PIE 4AYC 4EPO	2FF3 2LNH 2VCP
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Double-strand Break Repair Cell Cycle Process Cellular Response To Stress Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cell Cycle Postreplication Repair Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination DNA Damage Checkpoint Protein K48-linked Ubiquitination Response To Stress Mitotic DNA Damage Checkpoint Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Toll-like Receptor 4 Signaling Pathway Recombinational Repair Protein Catabolic Process DNA Double-strand Break Processing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Endocytosis Vesicle-mediated Transport Actin Filament-based Process Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cytoskeleton Organization Cell Projection Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Neuron Projection Morphogenesis Axon Guidance Fc Receptor Signaling Pathway Axonogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Phagocytosis Immune Response-regulating Signaling Pathway Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Chemotaxis Locomotion Actin Filament Organization Innate Immune Response Neuron Differentiation Organelle Organization Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Positive Regulation Of Actin Filament Polymerization Generation Of Neurons Positive Regulation Of Protein Polymerization Positive Regulation Of Immune System Process Regulation Of Protein Complex Assembly Neurogenesis Regulation Of Actin Cytoskeleton Organization Immune System Process Anatomical Structure Morphogenesis Transport Defense Response Regulation Of Immune Response
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Intersection) ?