RNF8 and TRIM29

Number of citations of the paper that reports this interaction (PubMedID 26381412)
31

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RNF8	TRIM29
Description		ring finger protein 8	tripartite motif containing 29
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break	Cytoplasm Lysosome Adherens Junction
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Interferon gamma signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)	Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)
Interacting Genes		78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496	55 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF13 RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM
Entrez ID		9025	23650
HPRD ID		11521	10280
Ensembl ID		ENSG00000112130	ENSG00000137699
Uniprot IDs		O76064	B7Z5V5 B7Z8U9 E9PRL4 Q14134
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV	2CSV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding	Negative Regulation Of Viral Transcription Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Nucleus Cytoskeleton Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Viral Transcription Regulation Of Skeletal Muscle Fiber Development Protein Ubiquitination Positive Regulation Of DNA Recombination Cytosol Positive Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Development Somatic Cell DNA Recombination Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Recombination Signal Transduction By P53 Class Mediator Suppression Of Viral Release By Host Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining Nucleoplasm Protein Modification Process Guanine/thymine Mispair Binding Positive Regulation Of Biosynthetic Process Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Catabolic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Development Regulation Of DNA Recombination Somatic Diversification Of Immunoglobulins Involved In Immune Response Regulation Of RNA Metabolic Process Negative Regulation Of Viral Process Macromolecule Catabolic Process Identical Protein Binding Protein Binding Signal Transduction In Response To DNA Damage Transcription Regulator Complex Positive Regulation Of Isotype Switching To IgA Isotypes
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