IRS2 and SOCS6

Number of citations of the paper that reports this interaction (PubMedID 12052866)
44

Data Source:
HPRD (in vitro)

		IRS2	SOCS6
Description		insulin receptor substrate 2	suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Immunological Synapse Cytoplasm Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding Phosphatidylinositol 3-kinase Activator Activity	Protein Binding Signaling Adaptor Activity
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Cell Migration Regulation Of Lipid Metabolic Process Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Endothelin	Defense Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of T Cell Activation
Pathways		PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling	Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		40 interacting genes: AP2M1 ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	38 interacting genes: ACVR1 AIRIM AMOT APPL1 AR BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		8660	9306
HPRD ID		02878	05491
Ensembl ID		ENSG00000185950	ENSG00000170677
Uniprot IDs		Q9P084 Q9Y4H2	O14544
PDB IDs		3FQW 3FQX	2VIF
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Protein Modification Process Insulin Receptor Substrate Binding Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Protein Phosphorylation Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Cell Adhesion Phosphorylation Regulation Of Immune System Process Regulation Of Cell Communication Regulation Of Signaling Cytokine-mediated Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Immune System Process Immune System Process Phosphate-containing Compound Metabolic Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Neurotrophin TRKA Receptor Binding Phosphoserine Residue Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cell Activation Protein Tyrosine Kinase Activity Regulation Of Intracellular Transport Phosphatidylinositol 3-kinase Complex Leukocyte Activation Lymphocyte Activation Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Regulation Of Leukocyte Cell-cell Adhesion Intracellular Signaling Cassette Regulation Of T Cell Activation	Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Migration Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Receptor Complex Protein Tyrosine Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Epidermal Growth Factor Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphatidylinositol 3-kinase Binding Growth Factor Binding Regulation Of Gene Expression Kinase Activity Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I ErbB-3 Class Receptor Binding Positive Regulation Of Metabolic Process Protein Modification Process ERBB2 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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