IRS2 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 8954948)
0

Data Source:
HPRD (in vitro)

		IRS2	IL4R
Description		insulin receptor substrate 2	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding Phosphatidylinositol 3-kinase Activator Activity	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Cell Migration Regulation Of Lipid Metabolic Process Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Endothelin	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion
Pathways		PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases			Asthma
GWAS		Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		40 interacting genes: AP2M1 ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		8660	3566
HPRD ID		02878	00990
Ensembl ID		ENSG00000185950	ENSG00000077238
Uniprot IDs		Q9P084 Q9Y4H2	B2RBY1 P24394
PDB IDs		3FQW 3FQX	1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Protein Modification Process Insulin Receptor Substrate Binding Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Protein Phosphorylation Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Cell Adhesion Phosphorylation Regulation Of Immune System Process Regulation Of Cell Communication Regulation Of Signaling Cytokine-mediated Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Immune System Process Immune System Process Phosphate-containing Compound Metabolic Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Neurotrophin TRKA Receptor Binding Phosphoserine Residue Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cell Activation Protein Tyrosine Kinase Activity Regulation Of Intracellular Transport Phosphatidylinositol 3-kinase Complex Leukocyte Activation Lymphocyte Activation Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Regulation Of Leukocyte Cell-cell Adhesion Intracellular Signaling Cassette Regulation Of T Cell Activation	Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process
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