IRS2 and UBTF

Number of citations of the paper that reports this interaction (PMID 12554758)
18

Data Source:
HPRD (in vivo)

		IRS2	UBTF
Gene Name		insulin receptor substrate 2	upstream binding transcription factor, RNA polymerase I
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleoplasm Nucleolus
	Molecular Function	Signal Transducer Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lipid Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Glucose Stimulus	Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase I Promoter
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ	31 interactors: CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		8660	7343
HPRD ID		02878	02814
Ensembl ID		ENSG00000185950	ENSG00000108312
Uniprot IDs		Q9P084 Q9Y4H2	P17480
PDB IDs		3FQW 3FQX	1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Organic Substance Cellular Response To Peptide Response To Peptide Hormone Response To Peptide Response To Organonitrogen Compound Response To Organic Substance Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Response To Hormone Cellular Response To Insulin Stimulus Cell Surface Receptor Signaling Pathway Response To Insulin Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Phosphorylation Innate Immune Response Defense Response Regulation Of Protein Kinase Activity Response To Stress Regulation Of Signal Transduction Regulation Of Immune System Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Response To Cytokine Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Protein Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding Regulation Of Intracellular Transport ERBB Signaling Pathway Locomotion	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Chromatin Silencing At RDNA Cellular Macromolecule Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Metabolic Process Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Cellular Biosynthetic Process Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway RRNA Transcription
Tagcloud ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Difference) ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Intersection) ?