IRS2 and PTPN6

  • Number of citations of the paper that reports this interaction (PMID 12198247)
  • 10
  • Data Source:
  • HPRD (in vivo)

IRS2

PTPN6

Gene Name insulin receptor substrate 2 protein tyrosine phosphatase, non-receptor type 6
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ 98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID 8660 5777
HPRD ID 02878 01475
Ensembl ID ENSG00000185950 ENSG00000111679
Uniprot IDs Q9P084 Q9Y4H2 P29350 Q53XS4
PDB IDs 3FQW 3FQX 1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
aacr  adaptive  adaptor  compensatory  conversely  cotargeting  dampen  dasatinib  ddr2  driven  emerged  gab1  harboring  igf1r  implicating  library  met  option  overlaying  panel  phosphoproteomics  py  rationale  res  rescued  rtk  scc  synergistic  weakly 
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  inositol  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
Tagcloud (Difference) ?
aacr  adaptive  adaptor  compensatory  conversely  cotargeting  dampen  dasatinib  ddr2  driven  emerged  gab1  harboring  igf1r  implicating  library  met  option  overlaying  panel  phosphoproteomics  py  rationale  res  rescued  rtk  scc  synergistic  weakly 
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  inositol  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
Tagcloud (Intersection) ?