IRS2 and ATP2A2

Number of citations of the paper that reports this interaction (PubMedID 9295312)
0

Data Source:
HPRD (in vitro, in vivo)

		IRS2	ATP2A2
Description		insulin receptor substrate 2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex Ribbon Synapse
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding Phosphatidylinositol 3-kinase Activator Activity	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Transmembrane Transporter Binding S100 Protein Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential LncRNA Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Cell Migration Regulation Of Lipid Metabolic Process Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Endothelin	Autophagosome Assembly Regulation Of The Force Of Heart Contraction Muscle System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction ER-nucleus Signaling Pathway Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Autophagosome Membrane Docking Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration T-tubule Organization Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Neuron Cellular Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Organelle Localization By Membrane Tethering Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Ritodrine Desflurane Sevoflurane Istaroxime
Diseases			Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 25056061 28991256 29483656 30285260) Waist circumference ( 28552196)
Interacting Genes		40 interacting genes: AP2M1 ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	20 interacting genes: ARLN BCL2 CAMK2A CCR4 CEBPA CHRM5 ELN F2RL1 FILNC1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 SRI TNFAIP3 TRIM14 TTC3
Entrez ID		8660	488
HPRD ID		02878	00161
Ensembl ID		ENSG00000185950	ENSG00000174437
Uniprot IDs		Q9P084 Q9Y4H2	A0A0S2Z3L2 P16615
PDB IDs		3FQW 3FQX	5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2 7E7S 7W7T 7W7U 7W7V 7W7W
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Protein Modification Process Insulin Receptor Substrate Binding Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Protein Phosphorylation Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Cell Adhesion Phosphorylation Regulation Of Immune System Process Regulation Of Cell Communication Regulation Of Signaling Cytokine-mediated Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Immune System Process Immune System Process Phosphate-containing Compound Metabolic Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Neurotrophin TRKA Receptor Binding Phosphoserine Residue Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cell Activation Protein Tyrosine Kinase Activity Regulation Of Intracellular Transport Phosphatidylinositol 3-kinase Complex Leukocyte Activation Lymphocyte Activation Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Regulation Of Leukocyte Cell-cell Adhesion Intracellular Signaling Cassette Regulation Of T Cell Activation	Negative Regulation Of Multicellular Organismal Process Response To Hormone Protease Binding Positive Regulation Of Transport Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Biological Quality Signal Transduction Response To Lipid Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Regulation Of System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Response To Vitamin Regulation Of Peptide Hormone Secretion Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Heart Contraction Sarcoplasmic Reticulum Negative Regulation Of Heart Rate Response To Steroid Hormone Regulation Of Calcium Ion Transport Negative Regulation Of Transport Protein Domain Specific Binding Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Regulation Of Protein Transport Tolerance Induction Calcium Ion Transport Response To Hydrogen Peroxide Regulation Of B Cell Apoptotic Process Regulation Of Blood Circulation Ubiquitin Binding Regulation Of Heart Rate Negative Regulation Of Heart Contraction Regulation Of Protein Secretion Insulin Receptor Binding Negative Regulation Of Blood Circulation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transmembrane Transport Protein Polyubiquitination Regulation Of Cellular Localization
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