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IRS2 and YWHAB
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
IRS2
YWHAB
Description
insulin receptor substrate 2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Biological Process
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Cell Migration
Regulation Of Lipid Metabolic Process
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Type B Pancreatic Cell Proliferation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lipid Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Endothelin
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Growth hormone receptor signaling
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Alanine aminotransferase levels (
34315874
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Aspartate aminotransferase levels (
34315874
)
Heel bone mineral density (
28869591
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
Insulin-related traits (multivariate analysis) (
32002517
)
Mean corpuscular hemoglobin (
27863252
29403010
32888494
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nose size (
27182965
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Platelet count (
29403010
)
Prostate cancer (
29117387
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Type 2 diabetes (
30297969
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter lesion progression (
26451028
)
White matter lesion progression (adjusted for white matter lesion burden at baseline) (
26451028
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
40 interacting genes:
AP2M1
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
MTDH
NEDD4
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SOCS1
SOCS3
SOCS6
SOCS7
SRPK2
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
8660
7529
HPRD ID
02878
03184
Ensembl ID
ENSG00000185950
ENSG00000166913
Uniprot IDs
Q9P084
Q9Y4H2
P31946
V9HWD6
PDB IDs
3FQW
3FQX
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Phosphotyrosine Residue Binding
Protein Modification Process
Insulin Receptor Substrate Binding
Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Binding
Protein Phosphorylation
Phosphatidylinositol 3-kinase Complex, Class IA
Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Adhesion
Phosphorylation
Regulation Of Immune System Process
Regulation Of Cell Communication
Regulation Of Signaling
Cytokine-mediated Signaling Pathway
Regulation Of Cellular Localization
Negative Regulation Of Immune System Process
Immune System Process
Phosphate-containing Compound Metabolic Process
Protein Metabolic Process
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Neurotrophin TRKA Receptor Binding
Phosphoserine Residue Binding
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Response To Stress
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Cell Population Proliferation
Cell Activation
Protein Tyrosine Kinase Activity
Regulation Of Intracellular Transport
Phosphatidylinositol 3-kinase Complex
Leukocyte Activation
Lymphocyte Activation
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphatase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Intracellular Signaling Cassette
Regulation Of T Cell Activation
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
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Tagcloud (Intersection)
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