EPOR and GAB2

Number of citations of the paper that reports this interaction (PMID 10455108)
20

Data Source:
HPRD (in vivo)

		EPOR	GAB2
Gene Name		erythropoietin receptor	GRB2-associated binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Cell Migration Osteoclast Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Phosphatidylinositol-mediated Signaling
Pathways			Signaling by GPCR Signaling by FGFR in disease G-protein beta:gamma signalling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by SCF-KIT Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Signaling by FGFR1 mutants Interleukin receptor SHC signaling Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants GPVI-mediated activation cascade Interleukin-2 signaling Signaling by FGFR1 fusion mutants Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs		Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS			Alzheimer's disease (late onset) ( 17553421) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1	28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70
Entrez ID		2057	9846
HPRD ID		00587	05866
Ensembl ID		ENSG00000187266	ENSG00000033327
Uniprot IDs		P19235	Q9UQC2
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX	2VWF 2W0Z
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response Positive Regulation Of Signal Transduction Blood Coagulation Intracellular Signal Transduction Regulation Of Immune System Process Hemostasis Positive Regulation Of Immune System Process Platelet Activation Positive Regulation Of Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune System Process Leukocyte Migration Defense Response T Cell Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Cell Activation T Cell Costimulation Regulation Of Cell-cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Response To Wounding Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Activation
Tagcloud ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k plasticity remarkable retained tamoxifen tetracycline tkis tumorigenesis
Tagcloud (Difference) ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit preformed recognition resolution spanning thought unliganded	adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k remarkable retained tamoxifen tetracycline tkis tumorigenesis
Tagcloud (Intersection) ?		plasticity