EPOR and KITLG

Number of citations of the paper that reports this interaction (PMID 11124255)
7

Data Source:
HPRD (in vivo)

		EPOR	KITLG
Gene Name		erythropoietin receptor	KIT ligand
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	Neural Crest Cell Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Melanocyte Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs		Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS			Blond vs. brown hair color ( 17952075) Hair color ( 23548203) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1	8 interactors: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		2057	4254
HPRD ID		00587	01698
Ensembl ID		ENSG00000187266
Uniprot IDs		P19235	P21583
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX	1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication	Erythropoietin-mediated Signaling Pathway Mast Cell Differentiation Cellular Response To Erythropoietin Mast Cell Chemotaxis Leukocyte Differentiation Myeloid Leukocyte Differentiation Cytokine Production Leukocyte Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemopoiesis Mast Cell Degranulation Cell Activation Mast Cell Mediated Immunity Fc-epsilon Receptor Signaling Pathway Immune System Development Embryonic Hemopoiesis Lysosome Localization Lymphocyte Differentiation Mast Cell Activation Myeloid Cell Differentiation Fc Receptor Signaling Pathway Leukocyte Degranulation Positive Regulation Of Cell Proliferation Organ Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulated Secretory Pathway Cellular Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Developmental Process Lymphocyte Activation Immune System Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Error-free Postreplication DNA Repair Mast Cell Proliferation Interleukin-1 Beta Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of JAK-STAT Cascade Embryonic Organ Development Reproductive Structure Development Reproductive System Development Immune Response Regulation Of Immune System Process Leukocyte Chemotaxis Response To Organic Substance T Cell Receptor Signaling Pathway System Development Kit Signaling Pathway
Tagcloud ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?