EPOR and RNF43

Number of citations of the paper that reports this interaction (PubMedID 37011906)
67

Data Source:
BioGRID (pull down)

		EPOR	RNF43
Description		erythropoietin receptor	ring finger protein 43
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Speck	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Decidualization	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation
Pathways		Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Hemoglobin levels ( 32327693) Iron status biomarkers (ferritin levels) ( 33536631) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Pancreatic cancer ( 20686608) Prostate cancer ( 29892016) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		42 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 RNF128 RNF43 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL ZNRF3	9 interacting genes: EPOR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N ZNRF3
Entrez ID		2057	54894
HPRD ID		00587	07896
Ensembl ID		ENSG00000187266	ENSG00000108375
Uniprot IDs		P19235	J3KSE3 Q68DV7
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6I4X 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL 8VUI 8VVM 8VVO	4KNG 8WVU
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Immune Effector Process Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Communication Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Activation Erythropoietin-mediated Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Cell Migration B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Motility Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Locomotion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cytosol Positive Regulation Of Mast Cell Proliferation	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Modification Process Transferase Activity Catabolic Process Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Nucleotide Binding Protein K63-linked Ubiquitination Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process Erythropoietin Receptor Activity Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination TOR Signaling Wnt Receptor Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex UBC13-MMS2 Complex Regulation Of BMP Signaling Pathway Nucleoplasm Negative Regulation Of Cellular Response To Growth Factor Stimulus ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Post-translational Protein Modification
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