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EPOR and IRS2
Number of citations of the paper that reports this interaction (PubMedID
9334184
)
0
Data Source:
HPRD
(in vivo)
EPOR
IRS2
Description
erythropoietin receptor
insulin receptor substrate 2
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Nuclear Speck
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Erythropoietin Receptor Activity
Protein Binding
Identical Protein Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Signal Transduction
Brain Development
Heart Development
Erythropoietin-mediated Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Decidualization
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Cell Migration
Regulation Of Lipid Metabolic Process
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Type B Pancreatic Cell Proliferation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lipid Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Endothelin
Pathways
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Growth hormone receptor signaling
Drugs
Darbepoetin alfa
Erythropoietin
Dibromotyrosine
Peginesatide
Methoxy polyethylene glycol-epoetin beta
Diseases
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Coronary artery disease (
29212778
)
Serum erythropoietin levels (
30271932
)
Alanine aminotransferase levels (
34315874
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Aspartate aminotransferase levels (
34315874
)
Heel bone mineral density (
28869591
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
Insulin-related traits (multivariate analysis) (
32002517
)
Mean corpuscular hemoglobin (
27863252
29403010
32888494
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nose size (
27182965
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Platelet count (
29403010
)
Prostate cancer (
29117387
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Type 2 diabetes (
30297969
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter lesion progression (
26451028
)
White matter lesion progression (adjusted for white matter lesion burden at baseline) (
26451028
)
Interacting Genes
42 interacting genes:
ATXN2L
CBL
CISH
CRKL
CSF2RB
EGLN3
ELOB
ELOC
EPO
GAB1
GAB2
GNAI1
GRAP
GRB2
INPP5D
IRS2
JAK2
KIT
KITLG
KLK3
LYN
MAPK1
MAPK3
MST1R
PIK3R1
PLCG1
PLCG2
PTPN11
PTPN6
RACK1
RNF128
RNF43
SH2B2
SHC1
SOCS2
SOCS3
STAT5A
STAT5B
SYK
VAV1
VHL
ZNRF3
40 interacting genes:
AP2M1
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
MTDH
NEDD4
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SOCS1
SOCS3
SOCS6
SOCS7
SRPK2
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
Entrez ID
2057
8660
HPRD ID
00587
02878
Ensembl ID
ENSG00000187266
ENSG00000185950
Uniprot IDs
P19235
Q9P084
Q9Y4H2
PDB IDs
1CN4
1EBA
1EBP
1EER
1ERN
2JIX
2MV6
4Y5V
4Y5X
4Y5Y
6E2Q
6I4X
6MOE
6MOF
6MOH
6MOI
6MOJ
6MOK
6MOL
8VUI
8VVM
8VVO
3FQW
3FQX
Enriched GO Terms of Interacting Partners
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Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytokine-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Leukocyte Proliferation
Positive Regulation Of Leukocyte Proliferation
Immune Effector Process
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune System Process
Regulation Of Immune Response
Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Lymphocyte Activation
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Regulation Of Cell Communication
Regulation Of Signaling
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Defense Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Activation
Erythropoietin-mediated Signaling Pathway
Natural Killer Cell Mediated Immunity
Regulation Of Lymphocyte Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Phosphorylation-dependent Protein Binding
Regulation Of Mononuclear Cell Proliferation
Myeloid Cell Differentiation
Growth Hormone Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of T Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of Cell Migration
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Immune System Process
Positive Regulation Of Cell Motility
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Locomotion
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Cytosol
Positive Regulation Of Mast Cell Proliferation
Signal Transduction
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Phosphotyrosine Residue Binding
Protein Modification Process
Insulin Receptor Substrate Binding
Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Binding
Protein Phosphorylation
Phosphatidylinositol 3-kinase Complex, Class IA
Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Adhesion
Phosphorylation
Regulation Of Immune System Process
Regulation Of Cell Communication
Regulation Of Signaling
Cytokine-mediated Signaling Pathway
Regulation Of Cellular Localization
Negative Regulation Of Immune System Process
Immune System Process
Phosphate-containing Compound Metabolic Process
Protein Metabolic Process
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Neurotrophin TRKA Receptor Binding
Phosphoserine Residue Binding
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Response To Stress
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Cell Population Proliferation
Cell Activation
Protein Tyrosine Kinase Activity
Regulation Of Intracellular Transport
Phosphatidylinositol 3-kinase Complex
Leukocyte Activation
Lymphocyte Activation
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphatase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Intracellular Signaling Cassette
Regulation Of T Cell Activation
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