EPOR and MST1R

Number of citations of the paper that reports this interaction (PMID 14982882)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EPOR	MST1R
Gene Name		erythropoietin receptor	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Stress Fiber Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	Movement Of Cell Or Subcellular Component Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Single Fertilization Positive Regulation Of Cell Proliferation Response To Virus Peptidyl-tyrosine Phosphorylation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase B Signaling
Pathways
Drugs		Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1	21 interactors: AKT1 EPOR GAB1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2057	4486
HPRD ID		00587	02545
Ensembl ID		ENSG00000187266	ENSG00000164078
Uniprot IDs		P19235	B4E058 Q04912
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX	3PLS 4FWW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication	Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Signaling Fc Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organic Substance Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Mitochondrion Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Mitochondrion Organization Signal Transduction Response To Peptide Hormone Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Organonitrogen Compound Cellular Response To Stimulus Response To Peptide Response To Organic Substance Signaling Apoptotic Signaling Pathway Defense Response Multicellular Organismal Development Cell Communication
Tagcloud ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Difference) ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Intersection) ?