EPOR and GRAP

Number of citations of the paper that reports this interaction (PubMedID 8647802)
0

Data Source:
HPRD (in vitro, in vivo)

		EPOR	GRAP
Description		erythropoietin receptor	GRB2 related adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Speck	Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Membrane Synapse Presynapse
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Decidualization	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Regulation Of MAPK Cascade
Pathways		Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Signaling by SCF-KIT
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Copper levels ( 26025379)
Interacting Genes		42 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 RNF128 RNF43 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL ZNRF3	18 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RBPMS REL SHC1 SOS1 TOX TRIM21
Entrez ID		2057	10750
HPRD ID		00587	05062
Ensembl ID		ENSG00000187266	ENSG00000154016
Uniprot IDs		P19235	I3L2P9 Q13588
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6I4X 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL 8VUI 8VVM 8VVO
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Immune Effector Process Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Communication Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Activation Erythropoietin-mediated Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Cell Migration B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Motility Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Locomotion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cytosol Positive Regulation Of Mast Cell Proliferation	Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Intracellular Signaling Cassette Regulation Of Immune System Process Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Lymphocyte Activation Regulation Of Multicellular Organismal Process SH2 Domain Binding Regulation Of Intracellular Signal Transduction T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Signal Transduction Leukocyte Activation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Erythropoietin-mediated Signaling Pathway CD4 Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Activation Cell Activation Positive Regulation Of Immune Response Phospholipase Activator Activity Regulation Of Multicellular Organismal Development Membrane Raft T Cell Receptor Binding ERBB Signaling Pathway Leukocyte Migration Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Regulation Of Lymphocyte Activation Phospholipase Binding
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