TOP3B and ADAMTSL4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TOP3B	ADAMTSL4
Gene Name		topoisomerase (DNA) III beta	ADAMTS-like 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Poly(A) RNA Binding	Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		18 interactors: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408	106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		8940	54507
HPRD ID		04662	18237
Ensembl ID		ENSG00000100038	ENSG00000143382
Uniprot IDs		A8K4N2 O95985	F8WAD0 Q6UY14 Q9UFG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Mast Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Mitral Valve Formation Cellular Macromolecule Biosynthetic Process Regulation Of Interferon-gamma Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcriptional Activation By Promoter-enhancer Looping Tricuspid Valve Formation Tricuspid Valve Morphogenesis Primitive Erythrocyte Differentiation Tricuspid Valve Development Blood Coagulation Hemostasis Regulation Of Definitive Erythrocyte Differentiation Regulation Of Mast Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Mitochondrial Translation Mitral Valve Morphogenesis Definitive Erythrocyte Differentiation Organelle Assembly Cellular Localization Negative Regulation Of Interleukin-4 Production Positive Regulation Of Dendritic Cell Chemotaxis Mitral Valve Development Elastic Fiber Assembly Chromosome Organization Protein Localization To Microtubule	Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?