TOP3B and GRN

Number of citations of the paper that reports this interaction (PubMedID 11549288)
0

Data Source:
HPRD (two hybrid)

		TOP3B	GRN
Description		DNA topoisomerase III beta	granulin precursor
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding
	Biological Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization
Pathways			Neutrophil degranulation
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1
Entrez ID		8940	2896
HPRD ID		04662	00733
Ensembl ID		ENSG00000100038	ENSG00000030582
Uniprot IDs		A8K4N2 O95985	P28799
PDB IDs		5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL	1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S
Enriched GO Terms of Interacting Partners?			Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding
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