TOP3B and CENPF

Number of citations of the paper that reports this interaction (PubMedID 11549288)
0

Data Source:
HPRD (two hybrid)

		TOP3B	CENPF
Description		DNA topoisomerase III beta	centromere protein F
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360) Serum immune biomarker levels ( 32066700)
Interacting Genes		25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		8940	1063
HPRD ID		04662	02582
Ensembl ID		ENSG00000100038	ENSG00000117724
Uniprot IDs		A8K4N2 O95985	A0A9L9PXU7 P49454
PDB IDs		5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?			Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion
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