TOP3B and FASTK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOP3B	FASTK
Description		DNA topoisomerase III beta	Fas activated serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity	Nucleotide Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fas-activated Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation	Mitochondrial RNA Processing Protein Phosphorylation Apoptotic Process Regulation Of RNA Splicing Regulation Of Mitochondrial MRNA Stability Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Eyebrow thickness ( 26926045)
Interacting Genes		25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	9 interacting genes: CALCOCO2 CHERP ESRRG MDFI PRPF31 RBPMS TIA1 TOP3B WIPF1
Entrez ID		8940	10922
HPRD ID		04662	07368
Ensembl ID		ENSG00000100038	ENSG00000164896
Uniprot IDs		A8K4N2 O95985	A0A090N8I0 A0A090N8Z7 Q14296
PDB IDs		5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?			RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Topoisomerase Activity Ribonucleoprotein Complex Localization Cytoplasmic Stress Granule DNA Topoisomerase III-beta-TDRD3 Complex U4atac SnRNP AF-2 Domain Binding Regulation Of MRNA Processing MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity MRNA CDS Binding SnRNP Binding U4atac SnRNA Binding Nucleic Acid Binding SnoRNA Localization
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