TOP3B and TDRD3

Number of citations of the paper that reports this interaction (PubMedID 34329467)
78

Data Source:
BioGRID (imaging technique, imaging technique, pull down)

		TOP3B	TDRD3
Description		DNA topoisomerase III beta	tudor domain containing 3
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Exon-exon Junction Complex DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Histone H3 Reader Activity Histone H4 Reader Activity
	Biological Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation	DNA Topological Change Chromatin Organization Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)
Interacting Genes		25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	7 interacting genes: FUS H3-4 POLR2A TOP3A TOP3B UBC USP9X
Entrez ID		8940	81550
HPRD ID		04662	11625
Ensembl ID		ENSG00000100038	ENSG00000083544
Uniprot IDs		A8K4N2 O95985	Q9H7E2
PDB IDs		5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL	1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T 8JTN 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?			DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity DNA Topoisomerase Activity DNA Topological Change DNA Conformation Change Amyloid Fibril Formation K11-linked Deubiquitinase Activity RNA Topoisomerase Activity DNA Binding DNA Repair DNA Topoisomerase III-beta-TDRD3 Complex Nucleus RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Binding RecQ Family Helicase-topoisomerase III Complex Isomerase Activity Chromosome Segregation Spermatogonial Cell Division Regulation Of RNA Splicing Chromosome Microfibril Binding DNA Metabolic Process Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Macromolecule Metabolic Process 5'-3' RNA Polymerase Activity DNA Damage Response DNA Replication-dependent Chromatin Assembly Positive Regulation Of TORC2 Signaling DNA Recombination Resolution Of DNA Recombination Intermediates Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Chromosome Separation DNA Alkylation Repair Nucleic Acid Metabolic Process Co-SMAD Binding Regulation Of TORC2 Signaling Prp19 Complex Protein Import Into Peroxisome Matrix Ubiquitin Protein Ligase Binding Protein Tag Activity RNA Polymerase II, Core Complex Molecular Sequestering Activity K63-linked Deubiquitinase Activity
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