TOP3B and RECQL5

Number of citations of the paper that reports this interaction (PubMedID 10710432)
40

Data Source:
HPRD (in vivo)

		TOP3B	RECQL5
Description		DNA topoisomerase III beta	RecQ like helicase 5
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA
	Biological Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Appendicular lean mass ( 33097823) Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		8940	9400
HPRD ID		04662	04806
Ensembl ID		ENSG00000100038	ENSG00000108469
Uniprot IDs		A8K4N2 O95985	B3KQK2 O94762
PDB IDs		5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL	4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?			Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair
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