TOP3B and C1QBP

Number of citations of the paper that reports this interaction (PMID 11549288)
1

Data Source:
HPRD (two hybrid)

		TOP3B	C1QBP
Gene Name		topoisomerase (DNA) III beta	complement component 1, q subcomponent binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Poly(A) RNA Binding	Complement Component C1q Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408	24 interactors: C1QA CEBPA COIL EXOSC6 GAB1 GABRB1 HABP4 HNRNPD HRK MAPK1 MAPK3 MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG
Entrez ID		8940	708
HPRD ID		04662	03168
Ensembl ID		ENSG00000100038	ENSG00000108561
Uniprot IDs		A8K4N2 O95985	Q07021
PDB IDs			1P32 3RPX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Mast Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Mitral Valve Formation Cellular Macromolecule Biosynthetic Process Regulation Of Interferon-gamma Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcriptional Activation By Promoter-enhancer Looping Tricuspid Valve Formation Tricuspid Valve Morphogenesis Primitive Erythrocyte Differentiation Tricuspid Valve Development Blood Coagulation Hemostasis Regulation Of Definitive Erythrocyte Differentiation Regulation Of Mast Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Mitochondrial Translation Mitral Valve Morphogenesis Definitive Erythrocyte Differentiation Organelle Assembly Cellular Localization Negative Regulation Of Interleukin-4 Production Positive Regulation Of Dendritic Cell Chemotaxis Mitral Valve Development Elastic Fiber Assembly Chromosome Organization Protein Localization To Microtubule	Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Defense Response Cellular Response To Organonitrogen Compound Regulation Of Protein Kinase Activity Response To Insulin Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Regulation Of Kinase Activity Cellular Response To Peptide Innate Immune Response Response To Organonitrogen Compound Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade Immune Response Regulation Of Phosphorylation Response To Hormone Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Response To Peptide Hormone Cell Death Death Regulation Of Phosphorus Metabolic Process
Tagcloud ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	133a a2m affymetrix afzelii borrelia burgdorferii burgeforii c1s cd46 cd59 cfb cfh complement cultivation defence differentiates diploid fhl1 garinii genospecies hgu launch penetrating sensu spirochaete spirochaetes stricto transcriptomes vsig4
Tagcloud (Difference) ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	133a a2m affymetrix afzelii borrelia burgdorferii burgeforii c1s cd46 cd59 cfb cfh complement cultivation defence differentiates diploid fhl1 garinii genospecies hgu launch penetrating sensu spirochaete spirochaetes stricto transcriptomes vsig4
Tagcloud (Intersection) ?