TOP3B and ZFPM1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		TOP3B	ZFPM1
Gene Name		topoisomerase (DNA) III beta	zinc finger protein, FOG family member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Transcriptional Repressor Complex
	Molecular Function	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper Cell Lineage Commitment Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Transcription, DNA-templated Heart Development Blood Coagulation Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Negative Regulation Of Protein Binding Regulation Of Chemokine Production Embryonic Hemopoiesis Megakaryocyte Development Positive Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Transcriptional Activation By Promoter-enhancer Looping
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408	6 interactors: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B
Entrez ID		8940	161882
HPRD ID		04662	11800
Ensembl ID		ENSG00000100038
Uniprot IDs		A8K4N2 O95985	Q8IX07
PDB IDs			2XU7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Mast Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Mitral Valve Formation Cellular Macromolecule Biosynthetic Process Regulation Of Interferon-gamma Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcriptional Activation By Promoter-enhancer Looping Tricuspid Valve Formation Tricuspid Valve Morphogenesis Primitive Erythrocyte Differentiation Tricuspid Valve Development Blood Coagulation Hemostasis Regulation Of Definitive Erythrocyte Differentiation Regulation Of Mast Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Mitochondrial Translation Mitral Valve Morphogenesis Definitive Erythrocyte Differentiation Organelle Assembly Cellular Localization Negative Regulation Of Interleukin-4 Production Positive Regulation Of Dendritic Cell Chemotaxis Mitral Valve Development Elastic Fiber Assembly Chromosome Organization Protein Localization To Microtubule	Eosinophil Fate Commitment Eosinophil Differentiation Granulocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Regulation Of Binding Negative Regulation Of Cellular Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Fat Cell Differentiation Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Basophil Differentiation Superior Temporal Gyrus Development Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Plasticity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Fat Cell Proliferation Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Neuron Maturation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Definitive Erythrocyte Differentiation Cellular Response To Interleukin-3 Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Binding Regulation Of Forebrain Neuron Differentiation Homeostasis Of Number Of Cells Myeloid Cell Differentiation Stem Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity
Tagcloud ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoiesis erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable
Tagcloud (Difference) ?		accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn	anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoiesis erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable
Tagcloud (Intersection) ?