CDC23 and SORBS3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CDC23	SORBS3
Name		cell division cycle 23	sorbin and SH3 domain containing 3
Structure
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Smooth Muscle Contraction
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Resting heart rate ( 27798624 )	Diastolic blood pressure ( 30224653 ) HIV-1 viral setpoint ( 20205591 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Parkinson's disease ( 28892059 )
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		8697	10174
HPRD ID		07221	11535
Ensembl ID		ENSG00000094880	ENSG00000120896
Uniprot IDs		Q9UJX2	O60504
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2CT3 2DLM 2NWM 2YUP
GO Terms Enriched among Interactors		None	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection