SORBS3 and DIP2A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SORBS3	DIP2A
Gene Name		sorbin and SH3 domain containing 3	DIP2 disco-interacting protein 2 homolog A (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleus Cell Surface
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Catalytic Activity Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Multicellular Organismal Development Metabolic Process Negative Regulation Of Gene Expression Regulation Of Apoptotic Process
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	18 interactors: ADAMTSL4 AES CCDC33 CEP44 DAB2 DLX2 FAM214B GPATCH2L JMJD6 MBIP PSME3 PTPN3 SORBS3 STAC3 TMCC2 TRIM39 TRIP13 ZBTB43
Entrez ID		10174	23181
HPRD ID		11535	07611
Ensembl ID		ENSG00000120896	ENSG00000160305
Uniprot IDs		O60504	Q14689 Q96NX2
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Proteolysis Negative Regulation Of Protein Binding Regulation Of Signaling Regulation Of Wnt Signaling Pathway Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Regulation Of Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Leading Edge Cell Differentiation Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Binding Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Clathrin-mediated Endocytosis Programmed Cell Death Negative Regulation Of Protein Catabolic Process Cell Death Death Cerebral Cortex GABAergic Interneuron Fate Commitment Liver Regeneration Positive Regulation Of Anoikis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Membrane Depolarization During Action Potential Positive Regulation Of Early Endosome To Late Endosome Transport Branching Morphogenesis Of A Nerve Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Binding Organ Development Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment
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