CDC23 and SLC52A2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CDC23	SLC52A2
Description		cell division cycle 23	solute carrier family 52 member 2
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Virus Receptor Activity Protein Binding Riboflavin Transmembrane Transporter Activity 4-hydroxybutyrate Receptor Activity
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Riboflavin Metabolic Process Riboflavin Transport Symbiont Entry Into Host Cell
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Vitamin B2 (riboflavin) metabolism
Drugs			gamma-Hydroxybutyric acid Sodium oxybate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	4 interacting genes: ADRB2 CDC23 CHRM2 FAM209A
Entrez ID		8697	79581
HPRD ID		07221	07431
Ensembl ID		ENSG00000094880	ENSG00000185803
Uniprot IDs		Q9UJX2	A0A6Q8PHF8 E9PKE4 Q9HAB3
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	8XSM
Enriched GO Terms of Interacting Partners?			Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Regulation Of Muscle Contraction Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy Regulation Of Muscle System Process AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Ciliary Basal Body Positive Regulation Of Autophagosome Maturation Adrenergic Receptor Activity Heat Generation Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Diet Induced Thermogenesis G Protein-coupled Receptor Activity Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Cholinergic Synapse Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Positive Regulation Of Organelle Organization Negative Regulation Of Systemic Arterial Blood Pressure Modulation Of Chemical Synaptic Transmission Positive Regulation Of CAMP/PKA Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Separation Protein Branched Polyubiquitination Regulation Of Exit From Mitosis Anaphase-promoting Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Adaptive Thermogenesis Anaphase-promoting Complex-dependent Catabolic Process Bone Resorption Regulation Of System Process Cilium
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