SORBS3 and TRIM23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SORBS3	TRIM23
Gene Name		sorbin and SH3 domain containing 3	tripartite motif containing 23
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Golgi Membrane Nucleus Lysosomal Membrane Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding Ligase Activity GDP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Small GTPase Mediated Signal Transduction Viral Process Protein Ubiquitination Positive Regulation Of Catalytic Activity
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	137 interactors: AKTIP ANKRD36BP1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 C10orf10 C19orf57 C8orf33 CARD9 CCDC146 CCDC25 CDC20B CDR2 CFAP53 COX5B CREB5 CXCL14 CYTH1 CYTH2 DCX DMC1 DMRT3 DOCK2 EAF2 EXOC3-AS1 FAM103A1 FAM110A FAM133A FAM193B FAM208B FAM83A FAM90A1 FBF1 FHIT FLAD1 FLJ38668 FXR2 GATA2 GEM GGA2 GMCL1P1 GPANK1 GPKOW HAUS1 HOXB5 HSPB7 IQCE IQUB JOSD1 KAT5 KIFC3 KLHL42 KRT6A LGALS8 LINC00526 LINC01018 LMO2 LNX1 LOC729603 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MTFR2 NEK6 NFU1 NXT2 PHF1 PIAS2 PIK3R2 PITX1 PKP4 POLI POLL POM121 PPIL2 PPP1R18 PSMA1 RAD18 RIBC2 RNF126 RNF213 RNF32 RNF34 RSRC2 RTP5 SF1 SH2D4A SIAH1 SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SORBS3 SPG21 STK19 SUMO1P1 TBC1D22B TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TROAP TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2U UBOX5 USP2 USP20 USP21 UTP23 WDR25 ZC2HC1C ZNF250 ZNF564 ZNF581
Entrez ID		10174	373
HPRD ID		11535	03449
Ensembl ID		ENSG00000120896	ENSG00000113595
Uniprot IDs		O60504	P36406
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cell Death Death Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Regulation Of Transcription, DNA-templated Regulation Of Proteolysis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?			344r abrogated adaptor antiviral conjugation defense e3 ectopic embryo helicase ikkgamma innate irf3 k165 k27 lys mda5 modulator multipoints nemo polyubiquitination rig substantially tightly tlr3 tlrs toll triparite ubiquitin
Tagcloud (Difference) ?			344r abrogated adaptor antiviral conjugation defense e3 ectopic embryo helicase ikkgamma innate irf3 k165 k27 lys mda5 modulator multipoints nemo polyubiquitination rig substantially tightly tlr3 tlrs toll triparite ubiquitin
Tagcloud (Intersection) ?