CDC23 and CDC16

Number of citations of the paper that reports this interaction (PubMedID 10318877)
0

Data Source:
HPRD (in vivo)

		CDC23	CDC16
Description		cell division cycle 23	cell division cycle 16
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)	Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	22 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B CDC20 CDC23 CDC27 CSTPP1 DAB2 DNAJA1 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5
Entrez ID		8697	8881
HPRD ID		07221	04587
Ensembl ID		ENSG00000094880	ENSG00000130177
Uniprot IDs		Q9UJX2	A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?			Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Sister Chromatid Separation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Positive Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Checkpoint Complex Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Separation Proteasomal Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Nuclear Division Cytosol Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Paraxial Mesoderm Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Proteolysis Spindle Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition
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