SORBS3 and DLG5

Number of citations of the paper that reports this interaction (PMID 12657639)
7

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SORBS3	DLG5
Gene Name		sorbin and SH3 domain containing 3	discs, large homolog 5 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Cytoplasm Plasma Membrane Cell-cell Adherens Junction
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Protein Complex Assembly Signal Transduction Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Polarized Epithelial Cell Differentiation Midbrain Development Intracellular Signal Transduction Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Epithelial Tube Branching Involved In Lung Morphogenesis Protein Localization To Adherens Junction Metanephric Collecting Duct Development
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	8 interactors: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		10174	9231
HPRD ID		11535	04972
Ensembl ID		ENSG00000120896	ENSG00000151208
Uniprot IDs		O60504	Q8TDM6
PDB IDs		2CT3 2DLM 2NWM 2YUP	1UIT
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphorylation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Segregation Positive Regulation Of MAPK Cascade Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Response To Drug Regulation Of Phosphorylation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Polymerization Regulation Of MAPK Cascade Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Telomeric Loop Formation Glial Cell Fate Determination Age-dependent Telomere Shortening Oviduct Development Regulation Of Centriole-centriole Cohesion Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Determination Of Dorsal Identity Telomere Maintenance Via Telomere Shortening Lung Induction Interleukin-1 Beta Secretion Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Tube Formation Cell Proliferation Morphogenesis Of Embryonic Epithelium
Tagcloud ?			12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Difference) ?			12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Intersection) ?