CDC23 and NRBF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDC23	NRBF2
Description		cell division cycle 23	nuclear receptor binding factor 2
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Autophagy Response To Endoplasmic Reticulum Stress
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)	Atrial fibrillation ( 30061737) Fasting glucose ( 34059833) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular telangiectasia type 2 ( 33654266) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 24026423) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell count ( 32888494) Schizophrenia ( 30285260 28991256) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	15 interacting genes: C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PPARA PRKAA2 RARA RHOU RPTOR RXRA SHANK3 THRB TSC1
Entrez ID		8697	29982
HPRD ID		07221	11401
Ensembl ID		ENSG00000094880	ENSG00000148572
Uniprot IDs		Q9UJX2	Q96F24
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	4ZEY
Enriched GO Terms of Interacting Partners?			Nuclear Receptor Activity Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Cell Size Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATP Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Monosaccharide Hormone-mediated Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Response To Carbohydrate Negative Regulation Of Hepatocyte Apoptotic Process Transcription Coactivator Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Regulation Of Glycolytic Process Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Intracellular Signal Transduction Cellular Response To Starvation MRNA Transcription TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus Response To Starvation Sequence-specific DNA Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Chromatin Binding Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Purine Nucleotide Metabolic Process
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