CDC23 and DCLK1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CDC23	DCLK1
Name		cell division cycle 23	doublecortin like kinase 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Cytoplasm Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Protein Phosphorylation Nervous System Development Central Nervous System Development Response To Virus Endosomal Transport Cell Differentiation Protein Localization To Nucleus Intracellular Signal Transduction Axon Extension
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	None
Drugs		None	Fostamatinib
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Resting heart rate ( 27798624 )	Familial squamous cell lung carcinoma ( 29924316 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 21998595 ) Interleukin-10 levels ( 22205395 ) Obesity-related traits ( 23251661 ) Optic cup area ( 25631615 28073927 31798171 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Post bronchodilator FEV1 ( 26634245 ) Vertical cup-disc ratio ( 20548946 31798171 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	4 interacting genes: APP CDC23 EFHC2 VPS26C
Entrez ID		8697	9201
HPRD ID		07221	09202
Ensembl ID		ENSG00000094880	ENSG00000133083
Uniprot IDs		Q9UJX2	A0A9L9PXT2 B7Z5K4 O15075 Q5VZY9
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	1MFW 1MG4 1UF0 5JZJ 5JZN 6KYQ 6KYR 7F3G 7KX6 7KX8 7KXW
GO Terms Enriched among Interactors		None	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Metaphase/anaphase Transition Of Mitotic Cell Cycle Heparan Sulfate Binding Signaling Receptor Activator Activity Metaphase/anaphase Transition Of Cell Cycle Peptidase Activator Activity Cellular Response To Manganese Ion Positive Regulation Of Cell Cycle Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel