SORBS3 and ZBTB25

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SORBS3	ZBTB25
Gene Name		sorbin and SH3 domain containing 3	zinc finger and BTB domain containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleoplasm Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	20 interactors: APIP COIL CYP2J2 DDIT3 FCGR3A HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 TNIP1 TRAF2 TSSK3 ZBTB1
Entrez ID		10174	7597
HPRD ID		11535	01926
Ensembl ID		ENSG00000120896
Uniprot IDs		O60504	P24278
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Signaling Protein Homooligomerization MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process MRNA Transcription Toll-like Receptor Signaling Pathway Protein Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Protein Homodimerization Activity Positive Regulation Of Immune Response Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Oligomerization Regulation Of Immune System Process Regulation Of Gene Expression Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Pro-T Cell Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Binding Positive Regulation Of Apoptotic Process
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