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CDC23
Gene Name
cell division cycle 23
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint
Regulation Of Exit From Mitosis
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions
44 interactors:
ANAPC10
ANAPC13
APOL1
ATRIP
BCAS3
BYSL
CCDC24
CCDC36
CDC16
CDH1
CDT1
CEP44
COIL
CRACR2A
CTBP1
CYB5R2
DLX6-AS1
EIF5A2
FAM9B
FBXO5
GORASP2
HEMK1
INCA1
INPP5J
KCTD6
KDM1A
LZTS2
MAPK3
OPTN
PNMA5
RAC1
RAD54B
RBM15B
RBPMS
RSL24D1
SIAH1
SLC52A2
SOX5
SPERT
SSX2IP
SUV39H1
TRIM27
TSC22D4
UBE2S
Entrez ID
8697
HPRD ID
07221
Ensembl ID
ENSG00000094880
Uniprot IDs
Q9UJX2
PDB IDs
Enriched GO Terms of Interacting Partners
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Protein K11-linked Ubiquitination
Cell Cycle
Regulation Of Organelle Organization
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Mitotic Cell Cycle
Protein Polyubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Cell Cycle Process
Mitotic Nuclear Division
Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Process
Regulation Of Chromosome Organization
Organelle Organization
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Cell Division
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Transferase Activity
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Chromosome Organization
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Cellular Component Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Transferase Activity
Protein Ubiquitination
Cell Cycle Checkpoint
Protein Modification By Small Protein Conjugation
Activation Of Anaphase-promoting Complex Activity
Regulation Of Mitotic Sister Chromatid Separation
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud
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34c
annexin
arrest
atlas
basal
breast
ccnd1
cdk4
cdk6
downregulated
ectopic
g2
incorporation
inducing
influenced
mediator
microrna
mimicked
mir
mirna
mirnas
mitotic
prkca
qpcr
sirnas
suppressed
suppressor
tcga
thymidine